1. Mr. Pausch, You have lead an amazing life and may your soul rest in peace.
2. Most of the lessons given by the professor are not generic. Most of them are very specific to his life, career and surroundings. For eg: his lesson on how to teach the students to be a good team player isn't really relevant to my life.
3. It may sound a bit unrealistic. Specially when he sounds like he achieved every single "specific" dream of his childhood. On the hindsight everything can be correlated. May be I was dumb as a kid but when I was little and would see a superhero movie, I would dream of being the superhero and not the person behind the special effects. I never knew kids were so matured. I might be wrong though.
4. And finally, with each chapter when you read how the professor lead such a perfect life achieving every single dream of his, You might get a feeling that he is bragging and that he is not down to earth. In his defense, he admits he is like that. I liked the honesty though.
Well that's about it. This book is not similar to the book "Tuesdays with Morrie" which is more about life in general. This one isn't. Although there a few good lessons but they are the usual ones like dream big, work hard, live life to the fullest, show gratitude, etc. You can skip this one since you won't find much you can relate to.